9   International Workshop on Chemical Exchange Saturation Transfer Imaging

th

CEST 2022

Video recordings of CEST 2022 are available

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CEST 2022 program and abstracts are available

 

Program (follows Eastern Standard Time)

Day 0 - Sunday, 7 August 2022 

14:00~17:00

Registration

Emory Conference Hotel Amphitheater

16:00~18:00

Education Session (newcomers to the CEST field)

(Peter van Zijl, Ph.D., Dean Sherry, Ph.D., Ravinder Reddy, Ph.D.)

16:00~

Basics of the Z-spectrum, CEST, NOE, and MTC,

Peter van Zijl, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA

16:40~

paraCEST agents: opportunities & Limitations,

Dean Sherry, Ph.D., University of Texas Southwestern Medical Center, Dallas, TX, USA

17:20~

Basics of T1 Relaxation in the Rotating Frame (T1p)  and Chemical Exchange Under Spin-Locking

Ravinder Reddy, Ph.D., University of Pennsylvania, Philadelphia, PA, USA

18:00~20:00

Opening Reception

Emory Conference Hotel Silverbell Pavilion

Day 1 - Monday, 8 August 2022 

08:00~08:10

Welcome

Phillip Zhe Sun, Ph.D., Elizabeth Krupinski, Ph.D.

08:15~09:15

Keynote Lecture

Moderator: Peter van Zijl, Ph.D.

08:15~

Imaging of sugar-based contrast agents: challenges and opportunities, 

Linda Knutsson, Ph.D., Lund University, Sweden

08:45~

Imaging Exchange with T1rho

John Gore, Ph.D., Vanderbilt University, Nashville, TN, USA

09:15~09:30

15 min break

09:30~10:20

Session 1: CEST Methods and Rigor

Moderators: Tao Jin, Ph.D., Ravinder Reddy, Ph.D. 

09:30~

Invited Talk: QUASS CEST MRI

Phillip Zhe Sun, Ph.D., Emory University, Atlanta, GA, USA

09:45~

Quantification of Electrostatic Molecular Binding Model Using the Water Proton Signal,

Peter van Zijl, Johns Hopkins University School of Medicine, Baltimore, MD, USA

09:52~

Optimization of Saturation Power for pH-weighted MRI in Stroke Rodents,

Julius Chung, University of Pittsburgh, Pittsburgh, PA, USA

09:59~

Guanidinium and amide CEST mapping of human brain by high spectral resolution CEST at 3T,

Kexin Wang, Johns Hopkins University School of Medicine, Baltimore, MD, USA

10:06~

Phosphate Form Spectroscopically Dark State Assembly Formation in Common Aqueous Solutions,

Jiaqi Lu, New York University, New York, NY, USA

10:13~

Q & A

10:20~10:30

10 min break

10:30~11:20

Session 2: CEST in Oncology 1

Moderators: Xiang Xu, Ph.D., Daniel Gochberg, Ph.D.

10:30~

Invited Talk: Sugar CEST

Gil Navon, Ph.D., Tel Aviv University, Israel

10:45~

A pH-sensitizer can improve cancer immunotherapy treatment as monitored with acidoCEST MRI,

Renee L. Chin, University of Texas MD Anderson Cancer Center, Houston, TX, USA

10:52~

ALAw-CEST MRI of the ASCT2 transporter in a mouse model of prostate cancer,

Behnaz Ghaemi, Johns Hopkins University School of Medicine, Baltimore, MD, USA

10:59~

Implementing a new spatial filter for improving clinical brain tumor APTw contrast at 3T,

Feriel Romdhane, National Research Council of Italy (CNR), Torino, Italy

11:06~

Evaluation of contributors to APT-weighted imaging and NOE-weighted imaging in tumors at high fields, Zhongliang Zu, Vanderbilt University Medical Center, Nashville, TN, USA

11:13~

Q & A

11:20~11:30

10 min break

11:30~12:30

Group Discussion 1: Rigor in CEST measurement

Moderator: Greg Stanisz, Ph.D.

12:30~14:00

Lunch

14:00~15:00

Session 3: Novel CEST Methods/Processing/Applications

Moderators: Zhongliang Zu, Ph.D., Michael McMahon, Ph.D.

14:00~

Invited Talk: Adventures in Machine learning for CEST fingerprinting

Christian Farrar, Ph.D., MGH and Harvard Medical School, Charlestown, MA, USA

14:15~

A Generative Adversarial Network for Accelerated and Quantitative 3D Semisolid MT/CEST MRI: a Multi-Center Brain and Leg Human Study, Jonah P. W. Weigand, MGH and Harvard Medical School, Charlestown, MA, USA

14:22~

Which method provides most insight into tumors – 3T (fluid suppr.) APTw, 3T CEST-MRF or 7T multi-pool CEST?, Maria Sedykh, University Hospital Erlangen, Erlangen, Germany

14:29~

Improved Bloch fitting and machine learning methods that analyze acidoCEST MRI,

Li Tianzhe, University of Texas MD Anderson Cancer Center, Houston, TX, USA

14:36~

DeepCEST: Fast mapping of 7T CEST MRI parameters with uncertainty quantification,

Leonie Hunger, University Hospital Erlangen, Erlangen, Germany (Virtual presentation)

14:43~

Q & A

15:00~15:15

15 min break

15:15~16:15

Session 4: CEST in Neurology

Moderators: Kejia Cai, Ph.D., Seth Smith, Ph.D.

15:15~

Invited Talk: Clinical CEST imaging of Alzheimer’s disease and Parkinson’s disease

Jinyuan Zhou, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA

15:30~

A comparison of APT analyses in acute stroke – Demonstration of highly sensitive and specific pH-weighted MRI, Dongshuang Lu, MGH and Harvard Medical School, Charlestown, MA, USA

15:37~

Early-Stage Cerebral Glutamate Mapping in APPNL-F/NL-F Mouse Model of Alzheimer’s Disease Using GluCEST MRI, Narayan Datt Soni, University of Pennsylvania, Philadelphia, PA, USA

15:44~

Omega plot-based quantitative in vivo CEST MRI

Yang Ji, MGH and Harvard Medical School, Charlestown, MA, USA

15:51~

The application of the proton exchange rate (kex) of CEST MRI constructed from direct-saturation-removed Omega plots in ischemic stroke, Yiran Zhou, Tongji Medical College, Wuhan, China

15:58~

Q & A

16:15~16:30

15 min break

16:30~17:30

Group Discussion 2: How to measure exchange rate/concentration

Moderator: Tao Jin, Ph.D.

17:30~17:45

15 min break

20:30~21:30

Poster Session 1

Hickory Room

Day 2 - Tuesday, 9 August 2022 

08:15~08:45

Keynote Lecture (Virtual presentations)

Moderator: Jeff W.M. Bulte, Ph.D. 

08:15~

Transmembrane ion gradients using exchangeable and non-exchangeable properties of magnetic resonance, 

Fahmeed Hyder, Ph.D., Yale University, New Haven, CT, USA 

08:45~

Mixed signals –  past and future challenges for the understanding of in vivo CEST MRI, Moritz Zaiss, Ph.D., University Clinic Erlangen, Germany

09:15~09:30

15 min break

09:30~10:20

Session 5: CEST in Oncology 2

Moderators: Iris Yuwen Zhou, Ph.D., Junyuan Zhou, Ph.D.

09:30~

Invited Talk: Using CEST MRI to determine genetic markers in human gliomas

ShanShan Jiang, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA

09:45~

ssMT and APT-weighted CEST imaging predict clinical outcome in the first follow up after completion of radiotherapy in glioma patients at 3T, Florian Kroh, German Cancer Research Center (DKFZ), Heidelberg, Germany 

09:52~

Enhanced diagnostic performance of APT-weighted MRI to advanced non-contrast MRI techniques in patients with post-treatment high-grade gliomas, Qianqi Huang, Johns Hopkins University School of Medicine, Baltimore, MD, USA

09:59~

Improved diagnostic accuracy of Amide Proton Transfer weighted imaging versus Dynamic Susceptibility Contrast Perfusion for the discrimination of radiation necrosis from tumor progression in brain metastases, Lucia Nichelli, University Hospitals Pitié Salpêtrière - Charles Foix, Paris, France,

10:06~

Glioma response assessment by asymmetry-based, Lorentzian-fit-based and relaxation-compensated CEST MRI of the APT and ssMT is influenced by glioma location at 3T, Nikolaus v. Knebel Doeberitz, German Cancer Research Center (DKFZ), Heidelberg, Germany

10:13~

Q & A

10:20~10:30

10 min break

10:30~11:20

Session 6: Emerging CEST Thoughts and Development

Moderators: Guanshu Liu, Ph.D., Daniel Paech, Ph.D.

10:30~

Invited Talk: Towards specific amine CEST imaging and its interpretation

Zhongliang Zu, Ph.D., Vanderbilt University Medical Center, Nashville, TN, USA

10:45~

Fast Multi-slice Quasi-steady-state (QUASS) APT MRI – Application to Brain Tumor Patients at 3 Tesla,

Hahnsung Kim, Emory University, Atlanta, GA, USA

10:52~

Development of a standard phantom for CEST MRI,

Tianze Li, University of Texas MD Anderson Cancer Center, Houston TX, USA

10:59~

Fast WASAB1 post-processing: access to rapid B0 and B1 correction in clinical routine for CEST MRI,

Christos Papageorgakis, Olea Medical, La Ciotat, France

11:06~

Enhanced multipool fitting with quasi-steady-state (QUASS) CEST MRI,

Phillip Zhe Sun, Emory University, Atlanta, GA, USA

11:13~

Q & A

11:20~11:30

10 min break

11:30~12:30

Group Discussion 3: MTC and rNOE

Moderator: Peter van Zijl, Ph.D.

12:30~14:00

Lunch

14:00~15:00

Session 7: CEST in Body 

Moderators: Moriel Vandsburger, Ph.D., Rachelle Crescenzi, Ph.D.

14:00~

Invited Talk: Advances in cardiac CEST

Moriel Vandsburger, Ph.D., University of California, Berkeley, Berkeley CA, USA

14:15~

Spatial-Spectral Selective Pulses for B1 Compensation and Improved Saturation Homogeneity in Cardiac CEST, Cindy Ayala, University of California, Berkeley, Berkeley CA, USA 

14:22~

In vivo CEST-Dixon in axillary lymph nodes with and without biopsy-confirmed malignancy: potential for non-invasive determination of lymph node metastasis, Rachelle Crescenzi, Vanderbilt University Medical Center, Nashville, TN, USA

14:29~

Optimization of pH-Weighted CEST Contrast in the Spinal Cord,

Alicia Cronin, University of Western Ontario, London, ON, Canada

14:36~

The z-spectrum as a way to monitor fibrosis,

Nabeelah Jinnah, Sir Peter Mansfield Imaging Centre, University of Nottingham, United Kingdom

14:43~

Q & A

15:00~15:15

15 min break

15:15~16:15

Session 8: Responsive CEST contrast agents and delivery

Moderators: Alicia Cronin, Ph.D., Mark D. Pagel, Ph.D.

15:15~

Invited Talk: Functional imaging of the kidneys using CEST MRI

Michael McMahon, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA

15:30~

Quantitative imaging of gene therapy delivery vehicles using CEST-NMR/MRI,

Bonnie Lam, University of California, Berkeley, Berkeley CA, USA

15:37~

Simultaneous evaluations of pH and enzyme activity with a CEST MRI contrast agent,

Chathuri J. Kombala, University of Arizona, Tucson, AZ, USA

15:44~

Bioconjugation of Lactate CEST-Sensors to Virus Like Particles,

Laurel M. Hagge, University of Texas at Dallas, Richardson, TX, USA

15:51~

Determining the optimal saturation time for a CEST experiment,

Julius Chung, University of Pittsburgh, Pittsburgh, PA, USA

15:58~

Q & A

16:15~16:30

15 min break

16:30~17:30

Group Discussion 4: pH imaging

Moderator: Dean Sherry, Ph.D.

17:30~15:00

30 min break

18:00~20:00

Closing Reception

20:30~21:30

Poster Session 2

Hickory Room

Day 3 - Wednesday, 10 August 2022 

08:15~09:15

Session 9: Breakthrough Applications/Analysis/Sequences

Moderators: Jiadi Xu, Ph.D., Christian Farrar, Ph.D.

08:15~

Invited Talk: Theranostic CEST MRI: from small molecular drugs to nanomedicine

Guanshu Liu, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA

08:30~

Mapping pH using chemical exchange mediated stimulated echoes,

Yu Zhao, Vanderbilt University Medical Center, Nashville, TN, USA

08:37~

GraspCEST: 3D Steady-State CEST MRI Using Golden-Angle Radial Sparse MRI,

Rodolphe Leforestier, Icahn School of Medicine at Mount Sinai, New York, NY, USA

08:44~

SNR Optimized 3D EPI CEST Imaging Using Unevenly Segmented RF Irradiation,

Hahnsung Kim, Emory University, Atlanta, GA, USA

08:51~

New Advanced Principal Component Analysis method for an improved and safe clinical 3T CEST MRI denoising, Stefano Casagranda, Olea Medical, La Ciotat, France

08:58~

Q & A

09:30~09:45

15 min break

09:45~11:00

Session 10: CEST Preclinical/Clinical Translation/Partnership

Moderators: Hui Mao, Ph.D., Mark D. Pagel, Ph.D.

09:45~

Philips

10:00~

OleaMedical

10:15~

Bruker

10:30~

Siemens (Virtual)

10:45~

GE (Virtual)

11:00~11:15

15 min break

11:15~11:45

Panel Discussion - Academic/Industry Coordination

Moderators: Linda Knutsson, Ph.D., Daniel Paech, Ph.D.

11:45~11:50

Study Group Update

Jiadi Xu, Ph.D.

11:50~11:55

FareWell

Phillip Zhe Sun, Ph.D.

11:55~12:00

CEST 2024

Daniel Paech, Ph.D., Moritz Zaiss, Ph.D.

Poster Program 

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The Venue

Emory Conference Center Hotel

1615 Clifton Rd, Atlanta, GA 30329

The Emory Conference Center Hotel is the ideal combination of a tranquil and convenient location, a visionary Frank Lloyd Wright design, and an unparalleled dedication to service. Nestled next to Hahn Woods, a peaceful 26-acre nature preserve, our Atlanta accommodation offers a winning formula for productive conferences, and truly enjoyable leisure or business stays.

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