9 International Workshop on Chemical Exchange Saturation Transfer Imaging
th
CEST 2022
Video recordings of CEST 2022 are available
CEST 2022 program and abstracts are available
Program (follows Eastern Standard Time)
Day 0 - Sunday, 7 August 2022
14:00~17:00
Registration
Emory Conference Hotel Amphitheater
16:00~18:00
Education Session (newcomers to the CEST field)
(Peter van Zijl, Ph.D., Dean Sherry, Ph.D., Ravinder Reddy, Ph.D.)
16:00~
Basics of the Z-spectrum, CEST, NOE, and MTC,
Peter van Zijl, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA
16:40~
paraCEST agents: opportunities & Limitations,
Dean Sherry, Ph.D., University of Texas Southwestern Medical Center, Dallas, TX, USA
17:20~
Basics of T1 Relaxation in the Rotating Frame (T1p) and Chemical Exchange Under Spin-Locking
Ravinder Reddy, Ph.D., University of Pennsylvania, Philadelphia, PA, USA
18:00~20:00
Opening Reception
Emory Conference Hotel Silverbell Pavilion
Day 1 - Monday, 8 August 2022
08:00~08:10
Welcome
Phillip Zhe Sun, Ph.D., Elizabeth Krupinski, Ph.D.
08:15~09:15
Keynote Lecture
Moderator: Peter van Zijl, Ph.D.
08:15~
Imaging of sugar-based contrast agents: challenges and opportunities,
Linda Knutsson, Ph.D., Lund University, Sweden
08:45~
Imaging Exchange with T1rho
John Gore, Ph.D., Vanderbilt University, Nashville, TN, USA
09:15~09:30
15 min break
09:30~10:20
Session 1: CEST Methods and Rigor
Moderators: Tao Jin, Ph.D., Ravinder Reddy, Ph.D.
09:30~
Invited Talk: QUASS CEST MRI
Phillip Zhe Sun, Ph.D., Emory University, Atlanta, GA, USA
09:45~
Quantification of Electrostatic Molecular Binding Model Using the Water Proton Signal,
Peter van Zijl, Johns Hopkins University School of Medicine, Baltimore, MD, USA
09:52~
Optimization of Saturation Power for pH-weighted MRI in Stroke Rodents,
Julius Chung, University of Pittsburgh, Pittsburgh, PA, USA
09:59~
Guanidinium and amide CEST mapping of human brain by high spectral resolution CEST at 3T,
Kexin Wang, Johns Hopkins University School of Medicine, Baltimore, MD, USA
10:06~
Phosphate Form Spectroscopically Dark State Assembly Formation in Common Aqueous Solutions,
Jiaqi Lu, New York University, New York, NY, USA
10:13~
Q & A
10:20~10:30
10 min break
10:30~11:20
Session 2: CEST in Oncology 1
Moderators: Xiang Xu, Ph.D., Daniel Gochberg, Ph.D.
10:30~
Invited Talk: Sugar CEST
Gil Navon, Ph.D., Tel Aviv University, Israel
10:45~
A pH-sensitizer can improve cancer immunotherapy treatment as monitored with acidoCEST MRI,
Renee L. Chin, University of Texas MD Anderson Cancer Center, Houston, TX, USA
10:52~
ALAw-CEST MRI of the ASCT2 transporter in a mouse model of prostate cancer,
Behnaz Ghaemi, Johns Hopkins University School of Medicine, Baltimore, MD, USA
10:59~
Implementing a new spatial filter for improving clinical brain tumor APTw contrast at 3T,
Feriel Romdhane, National Research Council of Italy (CNR), Torino, Italy
11:06~
Evaluation of contributors to APT-weighted imaging and NOE-weighted imaging in tumors at high fields, Zhongliang Zu, Vanderbilt University Medical Center, Nashville, TN, USA
11:13~
Q & A
11:20~11:30
10 min break
11:30~12:30
Group Discussion 1: Rigor in CEST measurement
Moderator: Greg Stanisz, Ph.D.
12:30~14:00
Lunch
14:00~15:00
Session 3: Novel CEST Methods/Processing/Applications
Moderators: Zhongliang Zu, Ph.D., Michael McMahon, Ph.D.
14:00~
Invited Talk: Adventures in Machine learning for CEST fingerprinting
Christian Farrar, Ph.D., MGH and Harvard Medical School, Charlestown, MA, USA
14:15~
A Generative Adversarial Network for Accelerated and Quantitative 3D Semisolid MT/CEST MRI: a Multi-Center Brain and Leg Human Study, Jonah P. W. Weigand, MGH and Harvard Medical School, Charlestown, MA, USA
14:22~
Which method provides most insight into tumors – 3T (fluid suppr.) APTw, 3T CEST-MRF or 7T multi-pool CEST?, Maria Sedykh, University Hospital Erlangen, Erlangen, Germany
14:29~
Improved Bloch fitting and machine learning methods that analyze acidoCEST MRI,
Li Tianzhe, University of Texas MD Anderson Cancer Center, Houston, TX, USA
14:36~
DeepCEST: Fast mapping of 7T CEST MRI parameters with uncertainty quantification,
Leonie Hunger, University Hospital Erlangen, Erlangen, Germany (Virtual presentation)
14:43~
Q & A
15:00~15:15
15 min break
15:15~16:15
Session 4: CEST in Neurology
Moderators: Kejia Cai, Ph.D., Seth Smith, Ph.D.
15:15~
Invited Talk: Clinical CEST imaging of Alzheimer’s disease and Parkinson’s disease
Jinyuan Zhou, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA
15:30~
A comparison of APT analyses in acute stroke – Demonstration of highly sensitive and specific pH-weighted MRI, Dongshuang Lu, MGH and Harvard Medical School, Charlestown, MA, USA
15:37~
Early-Stage Cerebral Glutamate Mapping in APPNL-F/NL-F Mouse Model of Alzheimer’s Disease Using GluCEST MRI, Narayan Datt Soni, University of Pennsylvania, Philadelphia, PA, USA
15:44~
Omega plot-based quantitative in vivo CEST MRI
Yang Ji, MGH and Harvard Medical School, Charlestown, MA, USA
15:51~
The application of the proton exchange rate (kex) of CEST MRI constructed from direct-saturation-removed Omega plots in ischemic stroke, Yiran Zhou, Tongji Medical College, Wuhan, China
15:58~
Q & A
16:15~16:30
15 min break
16:30~17:30
Group Discussion 2: How to measure exchange rate/concentration
Moderator: Tao Jin, Ph.D.
17:30~17:45
15 min break
20:30~21:30
Poster Session 1
Hickory Room
Day 2 - Tuesday, 9 August 2022
08:15~08:45
Keynote Lecture (Virtual presentations)
Moderator: Jeff W.M. Bulte, Ph.D.
08:15~
Transmembrane ion gradients using exchangeable and non-exchangeable properties of magnetic resonance,
Fahmeed Hyder, Ph.D., Yale University, New Haven, CT, USA
08:45~
Mixed signals – past and future challenges for the understanding of in vivo CEST MRI, Moritz Zaiss, Ph.D., University Clinic Erlangen, Germany
09:15~09:30
15 min break
09:30~10:20
Session 5: CEST in Oncology 2
Moderators: Iris Yuwen Zhou, Ph.D., Junyuan Zhou, Ph.D.
09:30~
Invited Talk: Using CEST MRI to determine genetic markers in human gliomas
ShanShan Jiang, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA
09:45~
ssMT and APT-weighted CEST imaging predict clinical outcome in the first follow up after completion of radiotherapy in glioma patients at 3T, Florian Kroh, German Cancer Research Center (DKFZ), Heidelberg, Germany
09:52~
Enhanced diagnostic performance of APT-weighted MRI to advanced non-contrast MRI techniques in patients with post-treatment high-grade gliomas, Qianqi Huang, Johns Hopkins University School of Medicine, Baltimore, MD, USA
09:59~
Improved diagnostic accuracy of Amide Proton Transfer weighted imaging versus Dynamic Susceptibility Contrast Perfusion for the discrimination of radiation necrosis from tumor progression in brain metastases, Lucia Nichelli, University Hospitals Pitié Salpêtrière - Charles Foix, Paris, France,
10:06~
Glioma response assessment by asymmetry-based, Lorentzian-fit-based and relaxation-compensated CEST MRI of the APT and ssMT is influenced by glioma location at 3T, Nikolaus v. Knebel Doeberitz, German Cancer Research Center (DKFZ), Heidelberg, Germany
10:13~
Q & A
10:20~10:30
10 min break
10:30~11:20
Session 6: Emerging CEST Thoughts and Development
Moderators: Guanshu Liu, Ph.D., Daniel Paech, Ph.D.
10:30~
Invited Talk: Towards specific amine CEST imaging and its interpretation
Zhongliang Zu, Ph.D., Vanderbilt University Medical Center, Nashville, TN, USA
10:45~
Fast Multi-slice Quasi-steady-state (QUASS) APT MRI – Application to Brain Tumor Patients at 3 Tesla,
Hahnsung Kim, Emory University, Atlanta, GA, USA
10:52~
Development of a standard phantom for CEST MRI,
Tianze Li, University of Texas MD Anderson Cancer Center, Houston TX, USA
10:59~
Fast WASAB1 post-processing: access to rapid B0 and B1 correction in clinical routine for CEST MRI,
Christos Papageorgakis, Olea Medical, La Ciotat, France
11:06~
Enhanced multipool fitting with quasi-steady-state (QUASS) CEST MRI,
Phillip Zhe Sun, Emory University, Atlanta, GA, USA
11:13~
Q & A
11:20~11:30
10 min break
11:30~12:30
Group Discussion 3: MTC and rNOE
Moderator: Peter van Zijl, Ph.D.
12:30~14:00
Lunch
14:00~15:00
Session 7: CEST in Body
Moderators: Moriel Vandsburger, Ph.D., Rachelle Crescenzi, Ph.D.
14:00~
Invited Talk: Advances in cardiac CEST
Moriel Vandsburger, Ph.D., University of California, Berkeley, Berkeley CA, USA
14:15~
Spatial-Spectral Selective Pulses for B1 Compensation and Improved Saturation Homogeneity in Cardiac CEST, Cindy Ayala, University of California, Berkeley, Berkeley CA, USA
14:22~
In vivo CEST-Dixon in axillary lymph nodes with and without biopsy-confirmed malignancy: potential for non-invasive determination of lymph node metastasis, Rachelle Crescenzi, Vanderbilt University Medical Center, Nashville, TN, USA
14:29~
Optimization of pH-Weighted CEST Contrast in the Spinal Cord,
Alicia Cronin, University of Western Ontario, London, ON, Canada
14:36~
The z-spectrum as a way to monitor fibrosis,
Nabeelah Jinnah, Sir Peter Mansfield Imaging Centre, University of Nottingham, United Kingdom
14:43~
Q & A
15:00~15:15
15 min break
15:15~16:15
Session 8: Responsive CEST contrast agents and delivery
Moderators: Alicia Cronin, Ph.D., Mark D. Pagel, Ph.D.
15:15~
Invited Talk: Functional imaging of the kidneys using CEST MRI
Michael McMahon, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA
15:30~
Quantitative imaging of gene therapy delivery vehicles using CEST-NMR/MRI,
Bonnie Lam, University of California, Berkeley, Berkeley CA, USA
15:37~
Simultaneous evaluations of pH and enzyme activity with a CEST MRI contrast agent,
Chathuri J. Kombala, University of Arizona, Tucson, AZ, USA
15:44~
Bioconjugation of Lactate CEST-Sensors to Virus Like Particles,
Laurel M. Hagge, University of Texas at Dallas, Richardson, TX, USA
15:51~
Determining the optimal saturation time for a CEST experiment,
Julius Chung, University of Pittsburgh, Pittsburgh, PA, USA
15:58~
Q & A
16:15~16:30
15 min break
16:30~17:30
Group Discussion 4: pH imaging
Moderator: Dean Sherry, Ph.D.
17:30~15:00
30 min break
18:00~20:00
Closing Reception
20:30~21:30
Poster Session 2
Hickory Room
Day 3 - Wednesday, 10 August 2022
08:15~09:15
Session 9: Breakthrough Applications/Analysis/Sequences
Moderators: Jiadi Xu, Ph.D., Christian Farrar, Ph.D.
08:15~
Invited Talk: Theranostic CEST MRI: from small molecular drugs to nanomedicine
Guanshu Liu, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD, USA
08:30~
Mapping pH using chemical exchange mediated stimulated echoes,
Yu Zhao, Vanderbilt University Medical Center, Nashville, TN, USA
08:37~
GraspCEST: 3D Steady-State CEST MRI Using Golden-Angle Radial Sparse MRI,
Rodolphe Leforestier, Icahn School of Medicine at Mount Sinai, New York, NY, USA
08:44~
SNR Optimized 3D EPI CEST Imaging Using Unevenly Segmented RF Irradiation,
Hahnsung Kim, Emory University, Atlanta, GA, USA
08:51~
New Advanced Principal Component Analysis method for an improved and safe clinical 3T CEST MRI denoising, Stefano Casagranda, Olea Medical, La Ciotat, France
08:58~
Q & A
09:30~09:45
15 min break
09:45~11:00
Session 10: CEST Preclinical/Clinical Translation/Partnership
Moderators: Hui Mao, Ph.D., Mark D. Pagel, Ph.D.
09:45~
Philips
10:00~
OleaMedical
10:15~
Bruker
10:30~
Siemens (Virtual)
10:45~
GE (Virtual)
11:00~11:15
15 min break
11:15~11:45
Panel Discussion - Academic/Industry Coordination
Moderators: Linda Knutsson, Ph.D., Daniel Paech, Ph.D.
11:45~11:50
Study Group Update
Jiadi Xu, Ph.D.
11:50~11:55
FareWell
Phillip Zhe Sun, Ph.D.
11:55~12:00
CEST 2024
Daniel Paech, Ph.D., Moritz Zaiss, Ph.D.
Poster Program
The Venue
Emory Conference Center Hotel
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